Stay at the #1 Hotel in West Plains, Missouri!

When you step into Holiday Inn Express & Suites West Plains Southwest, you’ll quickly see why our guests’ reviews have made us the #1 hotel in West Plains, Missouri! Guests love sleeping on the comfortable mattresses in our spacious lodgings. Our pristine hotel is new and boasts amenities and services that equal our amazing reputation.

We know that life on the road can be hectic—we’re right off Highway 63 and W160. We offer a free hot breakfast every morning, with a hearty selection that includes biscuits and gravy, eggs, cinnamon rolls, as well as cold options like cereal, oatmeal, and pastries. To make your stay easy and stress-free, our hotel staff will be there to help you with anything you might need, or just to give you a complimentary cookie when you arrive at the front desk!

If you’re passing through the Ozarks for business, we have 2 meeting rooms with all the facilities you need to host a business meeting. We also offer WiFi throughout the hotel, including in your room, where you’ll also find ample workspace to sit down and focus. We’re a short trip from the West Plains Civic Center and Ozarks Medical Center.

West Plains Missouri

Holiday Inn Express West Plains, Missouri is close to all of the area's top attractions, restaurants, and shopping. We are conveniently located at the intersection of Highway 63 and 160. Just across from our hotel is Southern Hills Shopping center, with a variety of dining and shopping. In town, you can shop our local antique mall, with lots of treasures to be found, visit the Harlin Museum to learn about the history and stories of the Ozark, or discover the many things to do in West Plains!

Select from one of our five versatile room types and start planning your trip. Book your stay at the top hotel in West Plains, Missouri today!